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Effect of 2-DG on T-cell populations.

By Saurabh Singh (10870), Sanjay Pandey (656556), Anant Narayan Bhatt (764418), Richa Chaudhary (764419), Vikas Bhuria (764420), Namita Kalra (764421), Ravi Soni (764422), Bal Gangadhar Roy (423575), Daman Saluja (199971) and Bilikere S. Dwarakanath (199967)

Abstract

<p>(A) 2-DG had a differential and dose dependent effect on CD4<sup>+</sup> (decrease) and CD8<sup>+</sup> (increase) T-cell subpopulations reflected in reduced (B) CD4<sup>+</sup>/CD8<sup>+</sup> ratios. Lymphocytes from the spleen of control and 2-DG fed EAC tumor bearing mice were analyzed by flowcytometry to quantitate percentages of CD4<sup>+</sup> and CD8<sup>+</sup> populations. Also the effect of 2-DG administration on the (C) CD4<sup>+</sup>CD25<sup>+</sup> Treg cell population was determined in the peripheral circulation of non tumor bearing and EAC tumor bearing host by flowcytometry. 2-DG prevents tumor-induced augmentation of CD4<sup>+</sup>CD25<sup>+</sup> Treg cells in tumor-bearing mice compared to no alteration in the non tumor bearing mice. *, p < 0.05; **, p < 0.01; ***, p < 0.001</p

Topics: Ecology, Biological Sciences, serum insulin levels, blood glucose, hif, energy restriction, antitumor immunity, 3k, Mice BackgroundDietary energy restriction, tumor incidence, Drinking Water, pi, tumor growth, ERMA, pleotrophic factors, Hypoxia Inducible Factor, anticancer strategy, der, 3 months, mouse tumor model, dg, Glycolytic inhibitor, animal growth, eac, pcna, tumor implantation
Year: 2015
DOI identifier: 10.1371/journal.pone.0132089.g007
OAI identifier: oai:figshare.com:article/1472076
Provided by: FigShare
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