Silver(I)-Catalyzed Regioselective Construction of Highly Substituted α‑Naphthols and Its Application toward Expeditious Synthesis of Lignan Natural Products
Abstract
A novel route has been developed for regioselective synthesis of highly substituted α-naphthols, binaphthols, and anthracenol through silver(I) catalyzed C(sp<sup>3</sup>)–H/C(sp)–H, C(sp<sup>2</sup>)–H/C(sp)–H functionalization of β-ketoesters and alkynes, respectively, in a single step using water as a solvent. This protocol exhibited broad substrate scope and paved the way for synthesis of anticancer arylnaphthalene lignan natural products such as diphyllin, taiwanin E, and justicidin A with excellent selectivity- Dataset
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- Biophysics
- Biochemistry
- Molecular Biology
- Evolutionary Biology
- Ecology
- Hematology
- Plant Biology
- Computational Biology
- Environmental Sciences not elsewhere classified
- Chemical Sciences not elsewhere classified
- Physical Sciences not elsewhere classified
- Regioselective
- naphthol
- ketoester
- Application
- justicidin
- Construction
- anticancer arylnaphthalene lignan
- selectivity
- regioselective synthesis
- Substituted
- functionalization
- anthracenol
- Expeditious Synthesis
- Naphthol
- binaphthol
- taiwanin E
- substrate scope
- diphyllin
- Lignan Natural ProductsA novel route
- alkyne
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This paper was published in FigShare.
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