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Ampicillin reduces aortic atherosclerosis without affecting MDA levels.

By Ida Rune (442320), Bidda Rolin (304752), Christian Larsen (617025), Dennis Sandris Nielsen (129872), Jenny E. Kanter (847573), Karin E. Bornfeldt (45945), Jens Lykkesfeldt (300873), Karsten Buschard (293017), Rikke Kaae Kirk (847574), Berit Christoffersen (847575), Johannes Josef Fels (486363), Knud Josefsen (129874), Pernille Kihl (847576) and Axel Kornerup Hansen (129882)

Abstract

<p><b>A</b> Plaque burden assessed with the “en face”-method showed significantly lower plaque burden in the thoracic aorta in ampicillin-treated animals compared to untreated animals (<i>p</i> = 0.0285). <b>B</b> MDA levels measured at 16 weeks of age did not show any differences between the groups. <b>C</b> Histological assessment of the oil red O-positive area at the aortic sinus did not show any differences between the groups. <b>D</b> Histological slide of three representative aortic sinus lesions, demonstrating complex lesions with cholesterol clefts and necrotic cores (40X, Stained with Oil Red O). (Graphs depicted with mean ± SEM).</p

Topics: Biological Sciences, risk factors, aortic atherosclerotic lesion area, GM composition, gluten peptide gliadin, atherosclerosi, CVD risk factors, atherosclerotic plaque development, glucose tolerance, increase CVD risk factors, diet, novel treatment strategies, VLDL cholesterol levels
Year: 2016
DOI identifier: 10.1371/journal.pone.0146439.g006
OAI identifier: oai:figshare.com:article/1640815
Provided by: FigShare
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