Systolic blood pressure (SBP) after 5/6 nephrectomy (Nx) during the light period in mice fed a high-salt diet and a normal-salt diet.
<p>Fig 1A shows changes in SBP of high-salt diet (8% NaCl) groups after 6 weeks, whereas Fig 1B shows SBP changes in normal-salt diet (0.3% NaCl) groups. After 8 weeks, mice were administered drugs or vehicle. In high-salt groups, azilsartan significantly reduced SBP compared with candesartan and vehicle, and candesartan significantly reduced SBP compared with vehicle. In normal-salt diet groups, there were no significant differences in SBP. Data represent mean ± standard deviation. <i>n</i> = 3–6 for each group. *<i>P</i> < 0.05 azilsartan <i>vs</i>. vehicle, azilsartan <i>vs</i>. candesartan, and candesartan <i>vs</i>. vehicle. #<i>P</i> < 0.05 SBP (week 7) <i>vs</i>. SBP (week 6) for each group.</p
Biological Sciences, azilsartan group, NHE 3 transcription levels, angiotensin II type, 0.05 azilsartan vs, NHE 3 protein expression, NHE 3 expression, salt sensitivity, candesartan, azilsartan increases NHE 3 ubiquitination, Subtotal nephrectomized C 57BL mice, vehicle groups, blood pressure
DOI identifier: 10.1371/journal.pone.0147786.g001
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