Synthesis of 2,5-Disubstituted Oxazoles and Oxazolines Catalyzed by Ruthenium(II) Porphyrin and Simple Copper Salts


A novel and moderate synthesis of 2,5-disubstituted oxazoles and oxazolines involving ruthenium­(II) porphyrin–copper chloride catalyzed cyclization was developed. These reactions using readily available benzene carboxylic acids and phenylethenes or phenylacetylenes are performed under mild conditions. The reactions proceed in series, giving rise to the formation of an intermolecular C–N bond and an intramolecular C–O bond, which yield oxazole or oxazoline derivatives simultaneously

Similar works

Full text

oai:figshare.com:article/2525224Last time updated on 2/12/2018

This paper was published in FigShare.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.