Remote Stereocontrol in [3,3]-Sigmatropic Rearrangements: Application to the Total Synthesis of the Immunosuppressant Mycestericin G


The Ireland–Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote stereocontrol. This strategy has been used to synthesize the natural immunosuppressant mycestericin G and <i>ent</i>-mycestericin G, allowing for a revision of absolute configuration of this natural product

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oai:figshare.com:article/2553724Last time updated on 2/12/2018

This paper was published in FigShare.

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