Silica-Coated S<sup>2–</sup>-Enriched Manganese-Doped ZnS Quantum Dots as a Photoluminescence Probe for Imaging Intracellular Zn<sup>2+</sup> Ions


Detection of intracellular Zn<sup>2+</sup> has gained great attention because of its biological significances. Here we show the fabrication of silica-coated S<sup>2–</sup>-enriched Mn-doped ZnS quantum dots (SiO<sub>2</sub>–S–Mn–ZnS QDs) by enriching S<sup>2–</sup> with a silica shell on the surface of Mn-doped ZnS QDs via a sol–gel process for imaging intracellular Zn<sup>2+</sup> ions. The developed probe gave a good linearity for the calibration plot (the recovered PL intensity of the SiO<sub>2</sub>–S–Mn–ZnS QDs against the concentration of Zn<sup>2+</sup> from 0.3 to 15.0 μM), excellent reproducibility (1.2% relative standard deviation for 11 replicate measurements of Zn<sup>2+</sup> at 3 μM), and low detection limit (3s; 80 nM Zn<sup>2+</sup>). The SiO<sub>2</sub>–S–Mn–ZnS QDs showed negligible cytotoxicity, good sensitivity, and selectivity for Zn<sup>2+</sup> in a photoluminescence turn-on mode, being a promising probe for photoluminescence imaging of intracellular Zn<sup>2+</sup>

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oai:figshare.com:article/2592067Last time updated on 2/12/2018

This paper was published in FigShare.

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