10.1371/journal.pone.0151842.g002

Immunological Characterization of Plant-Based HIV-1 Gag/Dgp41 Virus-Like Particles - Fig 2

Abstract

<p><b>(A) Immunization scheme for systemic immunization</b>. Mice were given three priming immunizations on Weeks 0, 2, and 4, and two boosting immunizations on Weeks 8 and 10 (black arrows). Mice in Group 1 were primed and boosted with CTB-MPR; mice in Group 2 were primed with CTB-MPR and boosted with VLPs; mice in Group 3 were primed with VLPs and boosted with CTB-MPR, mice in Group 4 were primed and boosted with VLPs, and mice in Group 5 were mock immunized with plant derived proteins as described in the Methods. Blood samples were taken on Weeks 0, 2, 4, 8, 10, and 12 (red arrows). <b>(B) Immunization scheme for mucosal immunization</b>. Mice were given four priming immunizations on Weeks 0, 1, 2, and 3, and two boosting immunizations on Weeks 7 and 8 (black arrows). Mice in Group 1 were mucosally primed with VLPs and murabutide and systemically boosted with VLPs; mice in Group 2 were mucosally primed with VLPs and CT and systemically boosted with VLPs; mice in Group 3 were mucosally primed with VLPs and CT and systemically boosted with CTB-MPRs; mice in Group 4 were mucosally primed with CTB-MPR and CT and systemically boosted with VLPs; mice in Group 5 were mucosally primed with CTB-MPR and CT and systemically boosted with CTB-MPR, and mice in Group 6 were systemically primed and boosted with VLPs. Blood, fecal, and vaginal samples were taken on Weeks 0, 1, 3, 5, 7, 8, 10, and 12 (red arrows).</p

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oai:figshare.com:article/3956415Last time updated on 2/12/2018

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