Results from individual-based simulations, illustrating consequences of genetic conflict.


<p>(A) Same as the simulations in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005006#pcbi.1005006.g002" target="_blank">Fig 2</a> except that <i>a</i><sub>0</sub>, in addition to <i>a</i><sub><i>g</i></sub>, in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005006#pcbi.1005006.e012" target="_blank">Eq (5)</a> is determined by a single locus. The blue and red points (with error bars) show the deviating outcome for <i>m</i> = 0.10, <i>ρ</i> = 0.5, which is a consequence of genetic conflict between the cue locus and the locus encoding <i>a</i><sub><i>g</i></sub>: <i>a</i><sub><i>g</i></sub> became close to zero, but <i>a</i><sub>0</sub> became polymorphic, and the polymorphism at the original cue locus collapsed. The outcome is further illustrated in (B), showing a kernel-smoothed distribution of phenotypes in a typical simulation. The blue and red vertical lines show the prediction from <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005006#pcbi.1005006.g003" target="_blank">Fig 3C</a>, where <i>ρ</i> = 0, and the blue and red dashed lines the prediction from <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005006#pcbi.1005006.g003" target="_blank">Fig 3D</a>, where <i>ρ</i> = 0.5. The outcome where an unlinked modifier (<i>a</i><sub>0</sub>) takes over the polymorphism depends on the genetic architecture, as illustrated in (B), (C) and (D). In (C) the modifiers <i>a</i><sub>0</sub> and <i>a</i><sub><i>g</i></sub> in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005006#pcbi.1005006.e012" target="_blank">Eq (5)</a> are each determined by several loci with small additive effects, and the loci contributing to <i>a</i><sub>0</sub> all became polymorphic. In (D) there is a more complex architecture for <i>a</i><sub>0</sub>, with additive effects that in turn can be modified with an adjustable threshold limiting the amount of gene expression, and this threshold became polymorphic (see text and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005006#pcbi.1005006.s001" target="_blank">S1 Text</a> for further explanation).</p

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oai:figshare.com:article/3923622Last time updated on 2/12/2018

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