rVSV CVS G viruses are exposed to acidic pH within the cell body of DRG neurons.
Abstract
<p>Confocal microscopy of rVSV CVS G AF647 virions (blue) and the marker for acidified endosomes, LysoTracker (green) during uptake into DRG neurons pre-stained with CellTracker (CT) and NucBlue (NucB). Virus and LysoTracker were administered to the N compartment and localization of virions within acidified endosomes was assayed at 10hpi in the microchannel neurites, somal neurites and cell bodies. Dotted circles emphasize virions of interest.</p- Image
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- Medicine
- Cell Biology
- Neuroscience
- Pharmacology
- Biotechnology
- Evolutionary Biology
- Ecology
- Immunology
- Infectious Diseases
- Virology
- Environmental Sciences not elsewhere classified
- somal compartment
- membrane fusion
- rVSV CVS G uptake
- epithelial cells
- dorsal root ganglion
- Cell Body
- RABV
- rVSV CVS G
- Primary Peripheral Neurons
- endosomal transport
- entry steps
- endocytic markers
- Requires Fusion
- Clathrin Coated Pits
- Rabies Internalizes
- plasma membrane
- virion uptake
- clathrin pits
- stomatitis virus
- particle evidence
- microfluidic compartmentalized culture
- cell body
- G protein
- receptor engagement
- rabies infection
- rabies virus
- internalization mechanism
- transmission electron micrographs
- endosomal acidification
- chemical perturbation
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oai:figshare.com:artic...Last time updated on 2/12/2018This paper was published in FigShare.
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