Synthesis of a Masked 2,3-Diaminoindole


A three-step synthesis of masked 2,3-diaminoindole <b>1</b> from 2-iodo-3-nitro-1-(phenylsulfonyl)­indole (<b>2</b>) has been developed. Treatment of <b>1</b> with trifluoroacetic acid generates the unstable 2,3-diamino-1-(phenylsulfonyl)­indole (<b>3</b>), which can be trapped with α-dicarbonyl compounds to afford 5<i>H-</i>pyrazino­[2,3-<i>b</i>]­indoles <b>7</b>–<b>10</b>

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oai:figshare.com:article/4272989Last time updated on 2/12/2018

This paper was published in FigShare.

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