Abstract

<p><b>A)</b> Reactivity of PFD0020c domains against gC1qR and EPCR by ELISA-based binding assays. Antibody-mediated inhibition of <b>B)</b> binding to gC1qR or CD36 of <i>P</i>. <i>falciparum Pf3D7</i><sup><i>gC1qR</i></sup>, <i>Pf3D7</i><sup><i>CD36</i></sup>; <b>C)</b> binding to human brain endothelial cells (HBMEC) of <i>Pf3D7</i><sup><i>gC1qR</i></sup> and <b>D)</b> binding to gC1qR of four <i>P</i>. <i>falciparum</i> Mozambican isolates. The gC1qR binding levels in absence of antibodies were 299 IEs/mm<sup>2</sup> (SD 53) for <i>Pf</i>3D7<sup>gC1qR</sup>; 202 IEs/mm<sup>2</sup> (SD 11) for <i>Pf</i>moz1; 92 IEs/mm<sup>2</sup> (SD 17) for <i>Pf</i>moz2; 74 IEs/mm<sup>2</sup> (SD 8) for <i>Pf</i>moz3; and 81 IEs/mm<sup>2</sup> (SD 7) for <i>Pf</i>moz4. The CD36 binding level in absence of antibodies was 615 IEs/mm<sup>2</sup> (SD 27) for <i>Pf</i>3D7<sup>CD36</sup>. Binding is expressed as the percentage of mean binding in absence of antibodies. Bars represent the mean and standard deviation. * indicates <i>P</i><0.05 and **<i>P</i><0.001.</p

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oai:figshare.com:article/4229459Last time updated on 2/12/2018

This paper was published in FigShare.

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