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Effect of iminosugar treatment on guinea pig weight.

By Joanna L. Miller (3180228), Simon G. Spiro (3361217), Stuart D. Dowall (534412), Irene Taylor (111066), Antony Rule (2822144), Dominic S. Alonzi (1297545), Andrew C. Sayce (3180216), Edward Wright (188113), Emma M. Bentley (3361220), Ruth Thom (2549206), Graham Hall (585184), Raymond A. Dwek (156053), Roger Hewson (288208) and Nicole Zitzmann (90474)


<p>Female guinea pigs were treated via IV cannula TID with 1850 mg/kg/day <i>N</i>B-DNJ (n = 6), 120 mg/kg/day M<i>O</i>N-DNJ (n = 4) or placebo (n = 4) for 16 days. Weight change as a percentage of body weight on day 0 (baseline) is shown for placebo (black circle), <i>N</i>B-DNJ (blue square, including euthanised animal) and M<i>O</i>N-DNJ (orange triangle) treatment groups. Means for each group +/- standard deviation are plotted.</p

Topics: Microbiology, Ecology, Immunology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, EBOV glycoprotein pseudotyped virus assay, animal models, m O N-DNJ, iminosugar, 8 hour period, EBOV-infected guinea pigs, guinea pigs, M O N-DNJ, N B-DNJ, equally-spaced 8 hour intervals, Lethal Ebola Virus Guinea Pig Model
Year: 2016
DOI identifier: 10.1371/journal.pone.0167018.g001
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Provided by: FigShare
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