Effect of iminosugar treatment on guinea pig weight.
<p>Female guinea pigs were treated via IV cannula TID with 1850 mg/kg/day <i>N</i>B-DNJ (n = 6), 120 mg/kg/day M<i>O</i>N-DNJ (n = 4) or placebo (n = 4) for 16 days. Weight change as a percentage of body weight on day 0 (baseline) is shown for placebo (black circle), <i>N</i>B-DNJ (blue square, including euthanised animal) and M<i>O</i>N-DNJ (orange triangle) treatment groups. Means for each group +/- standard deviation are plotted.</p
Microbiology, Ecology, Immunology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, EBOV glycoprotein pseudotyped virus assay, animal models, m O N-DNJ, iminosugar, 8 hour period, EBOV-infected guinea pigs, guinea pigs, M O N-DNJ, N B-DNJ, equally-spaced 8 hour intervals, Lethal Ebola Virus Guinea Pig Model
DOI identifier: 10.1371/journal.pone.0167018.g001
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