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Structure of gangliosides and general scheme of biosynthesis (after Masson <i>et al</i>. [1]).

By Estelle Sibille (3595607), Olivier Berdeaux (172498), Lucy Martine (172505), Alain M. Bron (172515), Catherine P. Creuzot-Garcher (172512), Zhiguo He (586416), Gilles Thuret (172510), Lionel Bretillon (162840) and Elodie A. Y. Masson (3595610)

Abstract

<p>A. GGs are made of a ceramide moiety composed of a long chain base (LCB) and a fatty acid (FA) whose alkyl chains may vary, and on which an oligosaccharide chain is branched. GD3 34:1 (based on LIPID MAPS, systematic name: <a href="http://www.lipidmaps.org/tools/structuredrawing/StrDraw.pl?Mode=ProcessSPGlycanStrDraw&CoreAbbrev=Ceramide&CoreChainStyle=Bent&GlycanHeadGroupAbbrev=NeuAcalpha2-8NeuAcalpha2-3Galbeta1-4Glcbeta&HeadGroupDirection=left" target="_blank">NeuAcα2-8NeuAcα2-3Galβ1-4Glcβ-Cer</a>) is given as an example. The ceramide is composed of sphingosine (d18:1) as LCB and stearic acid (18:0) as FA. The oligosaccharide chain is made of one glucose, one galactose and two sialic acid residues. B. The formation of GGs is catalyzed by the sequential action of glycosyltransferases (<i>italic</i>). The main GG classes of the ganglio-series are represented with their common names, according to Svennerholm [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0168794#pone.0168794.ref002" target="_blank">2</a>].</p

Topics: Biochemistry, Medicine, Genetics, Neuroscience, Developmental Biology, Biological Sciences not elsewhere classified, ganglioside species, role, GD, retina, LC, GT, novel research directions, Tissue Specificities Gangliosides, Other Ocular Structures
Year: 2016
DOI identifier: 10.1371/journal.pone.0168794.g001
OAI identifier: oai:figshare.com:article/4486727
Provided by: FigShare
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