AgoshRNA molecules and CCR5 target sequences.
<p>13 AgoshRNAs against human CCR5 were designed. The target sequences in CCR5 mRNA (GenBank: AY874120) are shown with the position in subscript. The predicted structure of the AgoshRNA molecules by MFold is shown in the third column with the guide sequence boxed in grey and the bottom mismatch A C boxed in black. The potent shRNA sh1005 was included as positive control.</p
Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, infection Allogeneic transplantation, Dicer-independent RNAi pathways, Novel AgoshRNA molecules, CCR 5 co-receptor, AgoshRNA designs, potently downregulated CCR 5 expression, CCR 5 mRNA, PBMC, AgoshRNA processing yields, CCR 5 knockdown, CCR 5 tropic HIV, Short hairpin RNA, T cell development, cell growth assay, T cells, CCR 5 expression
DOI identifier: 10.1371/journal.pone.0177935.g002
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