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<i>Giardia</i> directly inhibits the growth of EPEC.

By Anna Manko (4114642), Jean-Paul Motta (640781), James A. Cotton (41548), Troy Feener (4114645), Ayodele Oyeyemi (4114648), Bruce A. Vallance (88578), John L. Wallace (319032) and Andre G. Buret (640782)

Abstract

<p><i>G</i>. <i>muris</i> trophozoites were co-incubated for 3h in Lysogeny broth (LB) media. Bacterial colonies were counted after plating and overnight incubation. (A) <i>G</i>. <i>muris</i> significantly reduces the growth of <i>C</i>. <i>rodentium</i>. (B) <i>G</i>. <i>duodenalis</i> significantly inhibits the growth of EPEC. All data are representative of n = 5–10/group and represented as mean±SEM. * p<0.05, ** p<0.01, *** p<0.001– compared to control group (CTR); # p<0.05, ### p<0.001 versus the corresponding group, indicated by line; n.d. means not detected, that is equivalent to 0; <i>G</i>.<i>d</i>. means <i>G</i>. <i>duodenalis</i>.</p

Topics: Medicine, Microbiology, Cell Biology, Immunology, Cancer, Science Policy, Infectious Diseases, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, host biology, HBD, mouse β- defensin 3, EPEC, epithelial cells, Giardia co-infection, enteropathogen-induced colitis, Giardia infection, cysteine protease inhibitors, antimicrobial peptides beta-defensin 2, markers release, Giardia spp, effacing bacteria-induced, Giardia duodenalis, microbial-microbial interactions, attenuated weight loss, trefoil factor 3, Giardia muris, diarrheal disease, host AMPs, Giardia modulates host responses, duodenalis trophozoites, disease outcome, Additional studies, novel mechanisms, antimicrobial peptides, Giardia infections, β- defensin 2, enteropathogenic Escherichia coli, TFF, Concomitant infections
Year: 2017
DOI identifier: 10.1371/journal.pone.0178647.g007
OAI identifier: oai:figshare.com:article/5114962
Provided by: FigShare
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