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Exposure to stress increased glucocorticoid receptor (GR) expression in splenic neutrophils.

By Blake T. Gurfein (4243417), Burcu Hasdemir (4243414), Jeffrey M. Milush (384458), Chadi Touma (319782), Rupert Palme (374917), Douglas F. Nixon (68367), Nicholas Darcel (4243411), Frederick M. Hecht (68366) and Aditi Bhargava (351640)

Abstract

<p>Scatter dot plot graphs of GR expression in (<b>A-E</b>) CD19<sup>+</sup> B cells, CD4<sup>+</sup> and CD8<sup>+</sup> T cells, monocytes (CD45<sup>+</sup>Thy1.2<sup>–</sup>CD19<sup>+</sup>CD11b<sup>+</sup>Ly6G<sup>-</sup>), and NK cells (CD45<sup>+</sup>Thy1.2<sup>–</sup>CD19<sup>+</sup>CD11b<sup>-</sup>CD49b<sup>+</sup>) in all four caging conditions and after CMS exposure. GR expression in <b>(F)</b> splenic neutrophils was significantly higher in mice exposed to CMS in both caging conditions. Data are mean ± SEM. <i>*</i>p <i>< 0</i>.<i>05</i>, <i>**</i>p <i>< 0</i>.<i>01</i>, <i>***p < 0</i>.<i>001</i>, <i>****p < 0</i>.<i>0001</i>.</p

Topics: Medicine, Cell Biology, Neuroscience, Evolutionary Biology, Immunology, Mental Health, Infectious Diseases, Environmental Sciences not elsewhere classified, B cells, frequency, CMS exposure, B lymphocyte composition, FCM, center B cells, stress exposure influence splenic B lymphocyte composition, spleen harbors one-fourth, zone B cells, EE-caged mice, caging conditions, EE-caged mice vs, Cntl-caged mice
Year: 2017
DOI identifier: 10.1371/journal.pone.0180771.g004
OAI identifier: oai:figshare.com:article/5200234
Provided by: FigShare
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