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MOESM6 of Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites

By Aleksandar Ilic (4586641), Sumin Lu (4586644), Vikram Bhatia (406012), Farhana Begum (4586647), Thomas Klonisch (231283), Prasoon Agarwal (246053), Wayne Xu (139880) and James Davie (3574571)

Abstract

Additional file 6. UCHL1 may interact with RAP1 as part of a nuclear scaffold complex. Nuclear scaffold lysate from DSP-treated DU 145 cells in RIPA buffer was incubated with an anti-UCHL1 antibody or control IgG. The immunoprecipitate (IP), and equal volumes of lysate (Input) and immunodepleted (ID) fractions were analyzed by immunoblotting with UCHL1 and RAP1 antibodies. Mouse/rabbit Rockland TrueBlot secondary antibodies were used

Topics: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Physiology, Developmental Biology, Chemical Sciences not elsewhere classified, UCHL1, Shelterin complex, Interstitial telomeric sites, Prostate cancer
Year: 2017
DOI identifier: 10.6084/m9.figshare.c.3927910_d6.v1
OAI identifier: oai:figshare.com:article/5593054
Provided by: FigShare
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