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A pilot study involving minimal ovarian stimulation for in vitro fertilization: extending the "follicle-stimulating hormone window" combined with the gonadotropin-releasing hormone antagonist cetrorelix

By D. de Jong, N.S. Macklon and B.C. Fauser


Objective: To study whether minimal interference in the process of selection of the single dominant follicle may serve as the basis for a simplified ovarian stimulation regimen for IVF. <br/><br/>Design: Single-center randomized pilot study. <br/><br/>Setting: Tertiary referral fertility center. <br/><br/>Patient(s): Fifteen normo-ovulatory patients with a regular indication for IVF. <br/><br/>Intervention(s): Ovarian stimulation for IVF was begun with 100 or 150 IU/d recombinant FSH starting on cycle day 5. From cycle day 8 or later, cotreatment was begun with 0.25 mg/d GnRH antagonist. No luteal support was provided. <br/><br/>Main Outcome Measure(s): Total number of dominant follicles and characteristics of the endocrine cycle. <br/><br/>Result(s): Multiple follicle development occurred in five of eight patients in the 100-IU group and in all seven women in the 150-IU group. Follicular phase and luteal phase lengths were normal, but the endocrine profile was abnormal. <br/><br/>Conclusion(s): A fixed daily dose of 150 IU recombinant FSH starting in the midfollicular phase resulted in ongoing growth of a restricted number of dominant follicles and sufficient oocytes retrieved to lead to ET. A marked reduction in the total amount of gonadotropins administered compared with standard treatment was achieved. Withholding luteal support did not exclude pregnancies

Topics: RG, RM
Year: 2000
DOI identifier: 10.1016/s0015-0282(00)00414-3
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Provided by: e-Prints Soton
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