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Hyperpolarized Lithium-6 as a Sensor of Nanomolar Contrast Agents

By Ruud van Heeswijk, Kai Uffmann, Arnaud Comment, Fiodar Kurdzesau, Chiara Perazzolo, Cristina Ramona Cudalbu, Sami Jannin, Jacobus A. Konter, Patrick Hautle, Ben van den Brandt, Gil Navon, Jacques Van Der Klink and Rolf Gruetter


Lithium is widely used in psychotherapy. The Li-6 isotope has a long intrinsic longitudinal relaxation time T-1 on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can be readily hyperpolarized within 30 min, while retaining a long polarization decay time on the order of a minute. We used the intrinsically long relaxation time for the detection of 500 nM contrast agent in vitro. Hyperpolarized lithium-6 was administered to the rat and its signal retained a decay time on the order of 70 sec in vivo. Localization experiments imply that the lithium signal originated from within the brain and that it was detectable up to 5 min after administration. We conclude that the detection of submicromolar contrast agents using hyperpolarized NIVIR nuclei such as Li-6 may provide a novel avenue for molecular imaging. Magn Reson Med 61:1489-1493, 2009. (C) 2009 Wiley-Liss, Inc

Publisher: 'Wiley'
Year: 2010
DOI identifier: 10.1002/mrm.21952
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