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A new ethylene glycol-silane monolayer for highly-specific DNA detection on Silicon Chips

By Sandro Carrara, Andrea Cavallini, Yuki Maruyama, Edoardo Charbon and Giovanni De Micheli


Monolayer thin films with ethylene-glycol function onto gold surfaces by using thiols have been extensively investigated. They have been proposed as precursors for applications to bio-detection, where their hydrophilic character improves both specificity and sensitivity. The aim of this letter is to characterize ethylene-glycol monolayer precursors formed onto silicon chips by using silanes. The importance of the ethylene-glycol function is demonstrated by comparing with the well known 3-Aminopropyltriethoxysilane. The different nano-scale structures of the two precursor monolayers are investigated by using atomic force microscopy (AFM). Longer, wider, and deeper grooves were measured in the images acquired on 3-Aminopropyltriethoxysilane. Fluorescence investigation demonstrates that the presence of ethylene-glycol function improves target hybridization onto silicon chips, assuring highly-specific detection of DNA

Publisher: 'Elsevier BV'
Year: 2010
DOI identifier: 10.1016/j.susc.2010.08.025
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