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Protective Effect of a Selective Prostaglandin E1 Receptor Agonist Against Warm Ischemia and Reperfusion Injury in Rat Kidney

By  房子 戸田


Maintaining the viability of an organ removed for transplantation is directly related to its survival. It has been reported that prostaglandin E1 (PGE1) reduces the ischemia-reperfusion injury of tissues. The protective effect of the selective PGE1 receptor agonist (ONO-AE1-329: Ono Pharmaceutical, Japan) on renal injury caused by warm ischemia-reperfusion was investigated in rats. After warm ischemia was applied to the left kidney for two hours in right nephrectomised Wistar rats, the renal blood flow was resumed and the animals were used as an experimental model. ONO-AE1-329, at 30 μg/kg was administered subcutaneously, three times daily for 7 days. In the non-treatment group, only the vehicle was administered daily after reperfusion. The ONO-AE1-329-treated animals were divided into three experimental groups according to the time of drug administration (group I: started from before ischemia, group II: started from immediately before reperfusion, group III: started from 6 hours after reperfusion). A comparison was made of the survival rate, renal function and histological findings. In the non-treatment group, the serum creatinine level increased with time and all the animals died within 4 days after ischemia and reperfusion. In contrast, the survival rate was significantly increased and the renal function improved 1 week later in the treatment group. Recovery of the renal function was significantly good and pathological impairment was suppressed in group I compared with groups II and III. Administration of ONO-AE1-329 provided histological protection against fatal renal failure. These findings suggest that warm ischemia-reperfusion injury can possibly be reduced by administration of ONO-AE1-329 to non-heart-beating organ donors

Publisher: 東京女子医科大学学会
Year: 2000
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