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Analysis of the Immunopathogenesis of Rheumatoid Arthritis and its Application to Novel Experimental Therapy(Advances of immunology in basic and clinical fields,Symposium)

By  正祥 針谷,  まさ子 原,  千賀子 深澤 and  禎夫 柏崎

Abstract

In synovia of patients with rheumatoid arthritis (RA), synoviocytes and infiltrating lymphocytes produce a variety of cytokines and contribute to the immunopathogenesis of the disease. In vitro culture of rheumatoid synovial cells revealed the following results; (1) Pro-inflammatory cytokine cascade exists in rheumatoid synovia. Tumor necrosis factor-α (TNF-α) and interleukin (IL)-1β locate upstream of the cascade, while IL-6, IL-8 and monocyte chemoattractant protein-1 locate downstream of it. (2) IL-4, IL-10, IL-13 and interferon-γ (IFN-γ) modulate the production of TNF-α, IL-1β, IL-1 receptor antagonist, IL-6 and IL-8 by rheumatoid synovial cells. (3) IL-10, but not IL-4, IL-13 or IFN-γ, is produced by rheumatoid synovia and IL-10 is the major anti-inflammatory cytokine in rheumatoid synovia. (4) Peptide containing nuclear localization sequence of NF-κB p50 inhibits TNF-α-induced IL-6 and IL-8 production. These data indicates that imbalance between pro- and anti-inflammatory cytokines would contribute to the persistence of synovial inflammation of RA and that NF-κB is a novel target of therapeutic approach against RA

Publisher: 東京女子医科大学学会
Year: 1997
OAI identifier: oai:ir.twmu.ac.jp:10470/23834
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