Location of Repository

Study of Plasma Ascorbic Acid Levels in Wheezing Children

By AN Nagdeote, PV Paunipagar, MG Muddeshwar and NP Suryawanshi

Abstract

Background: Reactive Oxygen species induced bronchial abnormalities may have important consequences in asthma, the main symptom being wheezing specially in children. Vitamin C is an important antioxidant known to quench the reactive oxygen species. A beneficial effect of fresh fruit consumption on lung function has been observed in several studies. Plasma levels Vitamin C was determined in relation to wheezing symptoms in cross sectional study. Methods: In a cross sectional blood samples of 50 patients attending pediatrics OPD, having wheezing and shortness of breath were analyzed for plasma Ascorbic acid level and compared with healthy controls of same age and sex. Results: The total number of 50 wheezing children were in the age group of 2 to 12 years with similar age matched controls. It was observed that the plasma ascorbic acid concentration in the wheezing children (0.43 – 0.12 mg/dl) was significantly decreased as compared to the normal controls ( 0.75 – 0.18 mg/dl ) P< 0.001. The highly significant low levels of plasma ascorbic acid level in wheezing children was irrespective of sex and severity of symptoms. However the ascorbic acid levels were at the lower side in female and with severe symptoms. Conclusions: Plasma Ascorbic acid levels were significantly, decreased in the process of scavenging the reactive oxygen species. Ascorbic acid directly neutralizes free radical and protects the bronchial tissue from oxidative injury, so it can be concluded that the consumption of fruit rich in vitamin C may reduce wheezing symptoms in children

Topics: Online Journal of Health and Allied Sciences
Publisher: BS Kakkilaya
Year: 2011
OAI identifier: oai:cogprints.org:7253
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://cogprints.org/7253/1/20... (external link)
  • http://cogprints.org/7253/ (external link)
  • Suggested articles

    Preview

    Citations

    1. A Simple colorimetric method for Ascorbic acid determination in blood plasma. Clinical chemica acta 1978;86:153.
    2. (2003). Ascorbic acid is decreased in induced sputum of mild asthmatic children. Inhal Toxicol
    3. (2000). Consumption of fresh fruit rich in vitamin C and wheezing symptoms in children. Thorax
    4. (1992). Dietary vitamin C intake and concentrations in the body fluids and cells of male smokers and nonsmokers.
    5. (1983). Douglas JS.Effect of ascorbic acid in response to methacholine challenge in asthmatic subjects. Am Rev Resp Dis
    6. (1992). Enhanced production of oxygen radical in nocturnal asthma. Am Rev Resp Dis
    7. Formation of epithelial basement membrane is restricted by scurvy in vitro and stimulated by vitamin C. doi
    8. (1995). Inhaled oxidants, and dietary antioxidants.
    9. Preliminary report on use of vitamin C in asthma.
    10. (1990). Reactive oxygen species and airway inflammation. Free radic Biol Med
    11. (1987). Role of zinc, copper and ascorbicacid in some common clinical pediatric problem.
    12. Serum levels of antioxidants vitamins ( alpha tocoferol , beta carotene ,and ascorbic acid) in children with bronchial asthma.
    13. (1979). The antioxidant Vitamin C. R C Crit Rev food sci Nutr
    14. Vitamin C entersmitochondria via facilitative glucose transporter 1 (glut 1) and confers mitochondrial protection against oxidative injury.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.