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Antioxidant activity of aqueous extract of Monascus fermented Indian variety of rice in high cholesterol diet fed-Streptozotocin diabetic rats, an in vivo study

By Int J Cur Sci Res. Kalaivani. M. Rajasekaran. A

Abstract

The present study was designed to investigate antioxidant activity of aqueous extract of Monascus fermented Indian variety of rice in high cholesterol diet fed- streptozotocin (STZ) induced diabetic rats.The Indian variety rice IR-532-E-576 was fermented with Monascus purpureus for 10 days and sterilized. High cholesterol fed-STZ-induced diabetic rats received aqueous extract of Monascus fermented Indian variety of rice at the concentration of 1.2 g / Kg of bw and 2.4 g / Kg bw daily for 30 days. The oxidative parameters like lipid peroxidation (LPO), reduced glutathione (GSH), superoxide dismutase (SOD) and catalase activities were assessed.High cholesterol diet and STZ increased the level of LPO and reduced the level of SOD, GSH and catalase, where as on administration of aqueous extract of Monascus fermented Indian variety of rice reduced the level of LPO to almost normal and increased the levels of GSH, SOD and catalase dose dependently.The present study concluded that consumption of Monascus fermented rice can be good dietary supplement for diabetes and hyperlipidemia

Topics: JOURNALS
Publisher: CurrentSciDirect Publications
Year: 2011
OAI identifier: oai:cogprints.org:7306
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