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Grey matter alterations co-localize with functional abnormalities in developmental dyslexia : an ALE meta-analysis

By Janosch Linkersdörfer, Jan Lonnemann, Sven Lindberg, Marcus Hasselhorn and Christian J. Fiebach

Abstract

The neural correlates of developmental dyslexia have been investigated intensively over the last two decades and reliable evidence for a dysfunction of left-hemispheric reading systems in dyslexic readers has been found in functional neuroimaging studies. In addition, structural imaging studies using voxel-based morphometry (VBM) demonstrated grey matter reductions in dyslexics in several brain regions. To objectively assess the consistency of these findings, we performed activation likelihood estimation (ALE) meta-analysis on nine published VBM studies reporting 62 foci of grey matter reduction in dyslexic readers. We found six significant clusters of convergence in bilateral temporo-parietal and left occipito-temporal cortical regions and in the cerebellum bilaterally. To identify possible overlaps between structural and functional deviations in dyslexic readers, we conducted additional ALE meta-analyses of imaging studies reporting functional underactivations (125 foci from 24 studies) or overactivations (95 foci from 11 studies ) in dyslexics. Subsequent conjunction analyses revealed overlaps between the results of the VBM meta-analysis and the meta-analysis of functional underactivations in the fusiform and supramarginal gyri of the left hemisphere. An overlap between VBM results and the meta-analysis of functional overactivations was found in the left cerebellum. The results of our study provide evidence for consistent grey matter variations bilaterally in the dyslexic brain and substantial overlap of these structural variations with functional abnormalities in left hemispheric regions

Topics: ddc:150
Year: 2012
OAI identifier: oai:publikationen.ub.uni-frankfurt.de:25855

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  1. (in press) A review and synthesis of the first 20 years of pet and fmri studies of heard speech, spoken language and reading.
  2. (2010). A common left occipitotemporal dysfunction in developmental dyslexia and acquired letter-by-letter reading? PLoS One 5.
  3. (2010). A dual-route perspective on poor reading in a regular orthography: an fmri study.
  4. (2008). A meta-analysis of functional neuroimaging studies of dyslexia.
  5. (1997). A positron emission tomographic study of impaired word recognition and phonological processing in dyslexic men.
  6. (2011). Activation likelihood estimation metaanalysis revisited.
  7. (2005). Ale metaanalysis: controlling the false discovery rate and performing statistical contrasts.
  8. (2003). Anatomical correlates of dyslexia: frontal and cerebellar findings.
  9. (2005). Anatomical signatures of dyslexia in children: unique information from manual and voxel based morphometry brain measures.
  10. (1999). Association of abnormal cerebellar activation with motor learning difficulties in dyslexic adults.
  11. (1980). Auditory temporal perception, phonics, and reading disabilities in children.
  12. (2007). Bias between mni and talairach coordinates analyzed using the icbm-152 brain template.
  13. (2007). Brain abnormalities in language disorders and in autism.
  14. (2007). Brain activation during sentence comprehension among good and poor readers.
  15. (2009). Brain classification reveals the right cerebellum as the best biomarker of dyslexia.
  16. (2009). Cerebellum and nonmotor function.
  17. (2009). Children with dyslexia lack multiple specializations along the visual word-form (vwf) system.
  18. (2007). Children with reading disorder show modality independent brain abnormalities during semantic tasks.
  19. (2008). Cognitive subtypes of dyslexia.
  20. (2009). Coordinatebased activation likelihood estimation meta-analysis of neuroimaging data: a random-effects approach based on empirical estimates of spatial uncertainty.
  21. (1979). Cytoarchitectonic abnormalities in developmental dyslexia: a case study.
  22. (2006). Deficient orthographic and phonological representations in children with dyslexia revealed by brain activation patterns.
  23. Demonet JF (2009)When all hypotheses are right: a multifocal account of dyslexia.
  24. (2007). Development of neural systems for reading.
  25. (2010). Developmental dyslexia in chinese and english populations: dissociating the effect of dyslexia from language differences.
  26. (2000). Developmental dyslexia: atypical cortical asymmetries and functional significance.
  27. (1985). Developmental dyslexia: four consecutive patients with cortical anomalies.
  28. (2008). Developmental dyslexia: Gray matter abnormalities in the occipitotemporal cortex.
  29. (2001). Developmental dyslexia: the cerebellar deficit hypothesis.
  30. (2004). Developmental dyslexia.
  31. (2010). Deviant processing of letters and speech sounds as proximate cause of reading failure: a functional magnetic resonance imaging study of dyslexic children.
  32. (1978). Difficulties in auditory organisation as a possible cause of reading backwardness.
  33. (2001). Disrupted neural responses to phonological and orthographic processing in dyslexic children: an fmri study.
  34. (2005). Dyslexia (specific reading disability).
  35. (2005). Dyslexia-a molecular disorder of neuronal migration: the 2004 norman geschwind memorial lecture.
  36. (2001). Dyslexia: cultural diversity and biological unity.
  37. (1979). Dyslexia: Research and theory.
  38. (2004). Dyslexia: the possible benefit of multimodal integration of fmri- and eeg-data.
  39. (2006). Evidence for a dysfunction of left posterior reading areas in german dyslexic readers.
  40. (1993). Evidence for a magnocellular defect in developmental dyslexia.
  41. (1994). Evidence for aberrant auditory anatomy in developmental dyslexia.
  42. (1999). Explicit and implicit processing of words and pseudowords by adult developmental dyslexics: A search for wernicke’s wortschatz?
  43. (1999). fmri during word processing in dyslexic and normal reading children.
  44. (2006). From genes to behavior in developmental dyslexia.
  45. (2009). Functional abnormalities in the dyslexic brain: a quantitative meta-analysis of neuroimaging studies.
  46. (2007). Functional and morphometric brain dissociation between dyslexia and reading ability.
  47. (1998). Functional connectivity of the angular gyrus in normal reading and dyslexia.
  48. (2002). Functional heterogeneity within broca’s area during verbal working memory.
  49. (2000). Functional neuroimaging studies of reading and reading disability (developmental dyslexia).
  50. (2009). Functional topography in the human cerebellum: a metaanalysis of neuroimaging studies.
  51. (2011). Gray matter volume changes following reading intervention in dyslexic children.
  52. (2005). Graymatter alteration in dyslexia: converging evidence from volumetric and voxel-by-voxel mri analyses.
  53. (2011). How many functional brains in developmental dyslexia? when the history of language delay makes the difference.
  54. (2001). Impaired processing of rapid stimulus sequences in dyslexia.
  55. (2008). Impaired semantic processing during sentence reading in children with dyslexia: Combined fmri and erp evidence.
  56. (1996). Is developmental dyslexia a disconnection syndrome? evidence from pet scanning.
  57. (2004). Keil A
  58. (2009). Meta-analysis of neuroimaging data: a comparison of image-based and coordinate-based pooling of studies.
  59. (2002). Meta-analysis of the functional neuroanatomy of single-word reading: method and validation.
  60. (2011). Meta-analyzing brain dysfunctions in dyslexic children and adults.
  61. (1998). Metabolic abnormalities in developmental dyslexia detected by 1h magnetic resonance spectroscopy.
  62. (2011). Minimizing withinexperiment and within-group effects in activation likelihood estimation meta-analyses. Hum Brain Mapp.
  63. (2008). Modifying the brain activation of poor readers during sentence comprehension with extended remedial instruction: a longitudinal study of neuroplasticity.
  64. (2005). More than words: a common neural basis for reading and naming deficits in developmental dyslexia?
  65. (2006). Neural basis of dyslexia: a comparison between dyslexic and nondyslexic children equated for reading ability.
  66. (2004). Neural changes following remediation in adult developmental dyslexia.
  67. (2004). Neuroanatomical markers for dyslexia: a review of dyslexia structural imaging studies.
  68. (2004). Neurobiology of dyslexia: a reinterpretation of the data.
  69. (2004). Neurobiology of specific language impairment.
  70. (2006). Neuropsychological deficits and neural dysfunction in familial dyslexia.
  71. (2003). On the automaticity/cerebellar deficit hypothesis of dyslexia: balancing and continuous rapid naming in dyslexic and adhd children.
  72. (2008). Perisylvian sulcal morphology and cerebral asymmetry patterns in adults who stutter.
  73. (1981). Phonemic deficits in developmental dyslexia.
  74. (2001). Preliminary evidence of widespread morphological variations of the brain in dyslexia.
  75. (2007). Procedural learning difficulties: reuniting the developmental disorders?
  76. (1999). Reading and dual-task balancing: evidence against the automatization deficit explanation of developmental dyslexia.
  77. (2009). Reading for meaning in dyslexic and young children: distinct neural pathways but common endpoints.
  78. (2009). Reduced neural integration of letters and speech sounds links phonological and reading deficits in adult dyslexia.
  79. (2004). Regional reductions of gray matter volume in familial dyslexia.
  80. (2002). Residual differences in language processing in compensated dyslexics revealed in simple word reading tasks.
  81. (2011). Structural brain alterations associated with dyslexia predate reading onset.
  82. (2009). Structural mri studies of language function in the undamaged brain.
  83. (2000). The angular gyrus in developmental dyslexia: task-specific differences in functional connectivity within posterior cortex.
  84. (2010). The cerebellum and language: historical perspective and review.
  85. (2008). The contribution of white and gray matter differences to developmental dyslexia: insights from dti and vbm at 3.0 t.
  86. (2011). The development of print tuning in children with dyslexia: evidence from longitudinal erp data supported by fmri.
  87. (2003). The development of reading impairment: a cognitive neuroscience model.
  88. (2011). The left occipitotemporal system in reading: disruption of focal fmri connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia.
  89. (2003). The myth of the visual word form area.
  90. (2004). The neurobiological basis of skilled and impaired reading: Recent findings and new directions.
  91. (2000). The visual word form area: spatial and temporal characterization of an Meta-Analysis Dyslexia
  92. (2003). Theories of developmental dyslexia: insights from a multiple case study of dyslexic adults.
  93. (1997). To see but not to read; the magnocellular theory of dyslexia.
  94. (2000). Voxel-based morphometry-the methods.
  95. (2009). Voxel-wise meta-analysis of grey matter changes in obsessivecompulsive disorder.

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