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Simultaneous determination of caffeine and theophylline using square wave voltammetry at poly(l-aspartic acid)/functionalized multi-walled carbon nanotubes composite modified electrode

By Birhanu Mekassa, Merid Tessema and Bhagwan Singh Chandravanshi

Abstract

A simple and reproducible poly(l-aspartic acid)/functionalized multi-walled carbon nanotubes composite modified glassy carbon electrode, P(LAsp)/f-MWCNTs/GCE, was constructed for simultaneous determination of caffeine and theophylline using square wave voltammetry. The electrode preserves and combines the properties of the individual modifiers synergistically. The electrochemical response of P(LAsp)/f-MWCNTs/GCE was characterized by cyclic voltammetry. A significant enhancement in the peak current response of CF and TP were observed accompanied with a negative shift in peak potential at the composite modified electrode compared to the bare electrode. The prepared P(LAsp)/f-MWCNTs/GCE exhibited excellent SWV response towards the simultaneous detection of CF and TP in the range of 1–150 and 0.1–50μM with limit of detection of 0.28 and 0.02μM (S/N=3), respectively. Real sample analysis has been successfully carried out in green tea, blood serum and pharmaceutical formulation of Panadol extra samples, which revealed good recovery results, 92.0–106%. The proposed sensor also displayed good selectivity, repeatability and reproducibility with appreciable long-term stability, indicating the feasibility and reliability. Keywords: Poly(l-aspartic acid)/functionalized multi-walled carbon nanotubes composite modified electrode, Square wave voltammetry, Simultaneous determination caffeine and theophylline, Green tea, Blood serum, Panadol extr

Topics: Engineering (General). Civil engineering (General), TA1-2040
Publisher: Elsevier
Year: 2017
DOI identifier: 10.1016/j.sbsr.2017.11.002
OAI identifier: oai:doaj.org/article:9c6f44c6839f431d8ab7b08d105830ac
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