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The Effect of Resveratrol on Cell Viability in the Burkitt’s Lymphoma Cell Line Ramos

By Paola Jara, Johana Spies, Constanza Cárcamo, Yennyfer Arancibia, Gabriela Vargas, Carolina Martin, Mónica Salas, Carola Otth and Angara Zambrano

Abstract

Resveratrol is a polyphenolic natural compound produced by a variety of crops. Currently, resveratrol is considered a multi-target anti-cancer agent with pleiotropic activity, including the ability to prevent the proliferation of malignant cells by inhibiting angiogenesis and curtailing invasive and metastatic factors in many cancer models. However, the molecular mechanisms mediating resveratrol-specific effects on lymphoma cells remain unknown. To begin tackling this question, we treated the Burkitt’s lymphoma cell line Ramos with resveratrol and assessed cell survival and gene expression. Our results suggest that resveratrol shows a significant anti-proliferative and pro-apoptotic activity on Ramos cells, inducing the DNA damage response, DNA repairing, and modulating the expression of several genes that regulate the apoptotic process and their proliferative activity

Topics: resveratrol, cell viability, Ramos cells, DNA damage, DNA repair, Organic chemistry, QD241-441
Publisher: MDPI AG
Year: 2017
DOI identifier: 10.3390/molecules23010014
OAI identifier: oai:doaj.org/article:c6631e6e4c974fff92a0164a7451918f
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