Location of Repository

New plant sources of the anti-cancer alkaloid, camptothecine from the Icacinaceae taxa, India

By BT Ramesha, HK Suma, U Senthilkumar, V Priti, G Ravikanth, R Vasudeva, TR Santhosh Kumar, KN Ganeshaiah and R Uma Shaanker


In this study, the production of camptothecine and its derivatives, in thirteen species of the family Icacinaceae, namely, Apodytes dimidiata, Codiocarpus andamanicus, Gomphandra comosa, Gomphandra coriacea, Gomphandra polymorpha, Gomphandra tetrandra, Iodes cirrhosa, Iodes hookeriana, Miquelia dentata, Miquelia kleinii, Natsiatum herpeticum, Pyrenacantha volubilis and Sarcostigma kleinii is reported. Seeds of M. dentata were found to produce the highest content of camptothecine (1.0–1.4% by dry weight of seeds). Full scan LC–MS and ESI-MS/MS analysis of M. dentata revealed, besides camptothecine, a number of other derivatives, namely, 10-hydroxycamptothecine, 9-methoxycamptothecine, 20-deoxycamptothecine. Crude extract preparations of the seeds of M. dentata were effective against a breast cancer cell line (IC50 = 3.82 g/ml for MDA MB273 cell lines) and two ovarian cancer cell lines (IC50 = 2.8 g/ml for NCI/ADR-RES and 4.5 g/ml for SKOV). These results are the first reports of camptothecine and its derivatives in these species and offer rich alternative plant sources for the anticancer compound, camptothecine

Topics: G Journal Papers
Publisher: Elsevier
Year: 2013
DOI identifier: 10.1016/j.phymed.2012.12.003
OAI identifier: oai:eprints.atree.org:344
Provided by: ePrints@ATREE
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://dx.doi.org/10.1016/j.ph... (external link)
  • http://eprints.atree.org/344/1... (external link)
  • http://eprints.atree.org/344/ (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.