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Terpenos isolados de Coussarea platyphylla Müll. Arg. (Rubiaceae)

By Francieli Casassa Vieira de Araujo, Fábio Gonçalves Marques, Cleuza Conceição da Silva, Silvana Maria de Oliveira Santin, Celso Vataru Nakamura, Maria Lucília Motinha Zamuner and Maria Conceição de Souza


The phytochemical investigation of Coussarea platyphylla led to the isolation of triterpenes betulonic and betulinic acid, monoterpenes monotropein and monotropein salt, the diterpene trans-phytol and esteroids. The structures of the isolated compounds were assigned on the basis of spectroscopic data, including two-dimensional NMR methods. The antiproliferative properties against human cancer cell lines and molluscicidal activity against Biomphalaria glabrata of the crude methanolic extract and of its fractions were investigated

Topics: Coussarea platyphylla, terpenes, antitumor
Publisher: Sociedade Brasileira de Química
Year: 2009
DOI identifier: 10.1590/s0100-40422009000700015
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