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Active Dendrites Enhance Neuronal Dynamic Range

By Leonardo L. GOLLO, Osame KINOUCHI and Mauro COPELLI

Abstract

Since the first experimental evidences of active conductances in dendrites, most neurons have been shown to exhibit dendritic excitability through the expression of a variety of voltage-gated ion channels. However, despite experimental and theoretical efforts undertaken in the past decades, the role of this excitability for some kind of dendritic computation has remained elusive. Here we show that, owing to very general properties of excitable media, the average output of a model of an active dendritic tree is a highly non-linear function of its afferent rate, attaining extremely large dynamic ranges (above 50 dB). Moreover, the model yields double-sigmoid response functions as experimentally observed in retinal ganglion cells. We claim that enhancement of dynamic range is the primary functional role of active dendritic conductances. We predict that neurons with larger dendritic trees should have larger dynamic range and that blocking of active conductances should lead to a decrease in dynamic range

Topics: HIPPOCAMPAL PYRAMIDAL NEURONS, SYNAPTIC INTEGRATION, ACTION-POTENTIALS, OLFACTORY-BULB, NETWORKS, CELL, BACKPROPAGATION, PLASTICITY, DROSOPHILA, MECHANISM, Biochemical Research Methods, Mathematical & Computational Biology
Publisher: PUBLIC LIBRARY SCIENCE
Year: 2009
DOI identifier: 10.1371/journal.pcbi.1000402
OAI identifier: oai:agregador.ibict.br.RI_USP:oai:www.producao.usp.br:BDPI/14999
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