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Conducting polymer- hydrogel blends for electrochemically controlled drug release devices

By Rosângela C. BARTHUS, Luiz M. LIRA and Susana I. Córdoba de TORRESI


Blends formed by electrochemical polymerization of polypyrrole (PPy) into polyacrylamide (PAAm) hydrogels were used as devices for controlled drug release. The influence of several parameters in the synthesis, such as type of hydrogel matrix and polymerization conditions was studied by using a fractional factorial design. The final goal was to obtain an adequate device for use in controlled release tests, based on electrochemical potential control. For controlled release tests, Safranin was used as model drug and release curves (amount of drug vs. time) have shown that these blends are promising materials for this use. The optimized blends obtained were characterized by cyclic voltammetry and Raman spectroscopy.Blendas formadas pela polimerização eletroquímica de pirrol em matriz de acrilamida (hidrogel) foram utilizadas, neste trabalho, como dispositivos para a liberação controlada de drogas. A influência de vários parâmetros nesta síntese, como tipo de matriz de hidrogel e condições de polimerização, foi estudada empregando-se planejamento fatorial fracionário. O objetivo final consistiu na obtenção de um material adequado para liberação baseada no controle de potencial. Para os testes de liberação foi utilizada Safranina, como substância modelo. As curvas de liberação demonstram a potencialidade do uso de tais dispositivos. Estes dispositivos foram também caracterizados por espectroscopia Raman e voltametria cíclica

Topics: Factorial design, Polypyrrole-polyacrilamide blends, Drug delivery, Electrochemically controlled release
Publisher: Sociedade Brasileira de Química
Year: 2008
DOI identifier: 10.1590/S0103-50532008000400004
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