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European Journal of Human Genetics

By Ronald Edward Blanton, Luciano K. Silva, Vanessa G. Morato, Antonio R. Parrado, Juarez Pereira Dias, Paulo Roberto Santana de Melo, Eliana A. G. Reis, Katrina A. B. Goddard, Márcio Roberto Teixeira Nunes, Sueli G. Rodrigues, Pedro F. C. Vasconcelos, Jesuina M. Castro, Mitermayer Galvão dos Reis, Mauricio Lima Barreto and Maria da Glória Lima Cruz Teixeira


p.762-765To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever(DHF)as well as 293 neighborhood cases of dengue fevre and 294 asymptomatic controls in Salvador, Bahia, Brazil.Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income,both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P=0.02, OR=0.28 and P=0.02,OR=0.13,respectively).Income or an index of income indicators, however,was also independently associated with the diagnosis of DHF

Topics: ethnicity, race, population structure, socioeconomic status, DENV3
Year: 2008
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