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Tumor immune escape in acute myeloid leukemia: Class II-associated invariant chain peptide expression as result of deficient antigen presentation

By Marvin M. van Luijn, Martine E. D. Chamuleau, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht and S. Marieke van Ham

Abstract

In this overview, we discuss the role of class II-associated invariant chain peptide (CLIP) in acute myeloid leukemia (AML), one of the few tumors expressing HLA class II. The clinical impact, function and regulation of CLIP expression on leukemic cells is addressed, indicating its potential as immunotherapeutic target in AM

Year: 2012
DOI identifier: 10.4161/onci.1.2.18100
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Provided by: NARCIS
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