Skip to main content
Article thumbnail
Location of Repository

Too large to fit? Recent developments in macromolecular imprinting.

By Yi Ge and Anthony P. F. Turner


Molecular imprinting involves the synthesis of polymers in the presence of a template to produce complementary binding sites with specific recognition ability. The technique has been successfully applied as a measurement and separation technology, producing a uniquely robust and antibody-like polymeric material. Low molecular weight molecules have been extensively exploited as imprint templates, leading to significant achievements in solid-phase extraction, sensing and enzyme-like catalysis. By contrast, macromolecular imprinting remains underdeveloped, principally because of the lack of binding site accessibility. In this review, we focus on the most recent developments in this area, not only covering the widespread use of biological macro-templates but also highlighting the emerging use of synthetic macro-templates, such as dendrimers and hyperbranched polymers

Publisher: Elsevier Science B.V., Amsterdam.
Year: 2008
DOI identifier: 10.1016/j.tibtech.2008.01.001
OAI identifier:
Provided by: Cranfield CERES

Suggested articles


  1. (2005). A method for the molecular imprinting of hemoglobin on silica surfaces using silanes. doi
  2. (2006). A stoichiometric molecularly imprinted polymer for the class-selective recognition of antibiotics in aqueous media. doi
  3. (2004). Adsorptive separation of hemoglobin by molecularly imprinted chitosan beads. doi
  4. (2008). APF; Too large to fit? Recent developments in macromolecular imprinting, doi
  5. (2006). Artificial antibodies for bioanalyte detection-sensing viruses and proteins. doi
  6. (2002). Bioimprinting of polymers and sol-gel phases. Selective detection of yeasts with imprinted polymers. doi
  7. (2005). Bovine serum albumin-imprinted polyacrylamide gel beads prepared via inverse-phase seed suspension polymerization. doi
  8. (2006). Capturing molecules with templated materials - analysis and rational design of molecularly imprinted polymers. doi
  9. (2004). Configurational biomimesis in drug delivery: molecular imprinting of biologically significant molecules. doi
  10. (2003). Cross-linked dendrimer hosts containing reporter groups for amine guests. doi
  11. (2004). Dendrimer-mediated formation of Cu-CuOx nanoparticles on silica and their physical and catalytic characterization. doi
  12. (2006). Dendrimers at work. doi
  13. (2006). Dendrimers for pharmaceutical and biomedical applications. doi
  14. eds (2003) Molecular Imprinting, doi
  15. eds (2005) Molecularly imprinted materials-science and technology, 1st edn. doi
  16. (2006). Emulsion and macromolecules templated alginate based polymer microspheres. doi
  17. (1995). Entrapment of enzymes using organo-functionalized polysiloxane copolymers. doi
  18. (2000). Facile sol-gel synthesis of porous silicas using poly(propylene)imine dendrimers as templates. doi
  19. (2007). Formation of protein molecular imprints within Langmuir monolayers: A quartz crystal microbalance study. doi
  20. (2006). From 3D to 2D: a review of the molecular imprinting of proteins. doi
  21. (2005). Hemoglobin recognition by imprinting in semi-interpenetrating polymer network hydrogel based on polyacrylamide and chitosan. doi
  22. (2003). Hierarchical imprinting using crude solid phase peptide synthesis products as templates. doi
  23. (2002). Hierarchically imprinted stationary phases: Mesoporous polymer beads containing surfaceconfined binding sites for adenine. doi
  24. (2004). Hyperbranched polymers: from synthesis to applications. doi
  25. (2005). Imprinted polymers. doi
  26. (2005). Imprinting unique motifs formed from protein-protein associations. doi
  27. (2006). Imprinting using dendrimers as templates. doi
  28. (2005). Improved imide receptors by imprinting using pyrimidine-based fluorescent reporter monomers. doi
  29. (1995). Influence of protein on polysiloxane polymer formation: Evidence for induction of complementary protein-polymer interactions. doi
  30. (2006). L-histidine imprinted synthetic receptor for biochromatography applications. doi
  31. (2003). Mass-sensitive detection of cells, viruses and enzymes with artificial receptors. doi
  32. (2007). Molecular imprinted particles for lysozyme purification. doi
  33. (2006). Molecular imprinting of polymers,
  34. (1998). Molecular imprinting technology: challenges and prospects for the future. doi
  35. (2006). Molecularly imprinted membranes for an improved recognition of biomolecules in aqueous medium. doi
  36. (2005). Molecularly imprinted polymers – potential and challenges in analytical chemistry. doi
  37. (2007). Molecularly imprinted polymers for the recognition of proteins: the state of art. doi
  38. (2004). Molecularly imprinted polymers prepared in aqueous solution selective for [Sar(1), Ala(8)]angiotensin II. doi
  39. (2003). Molecularly imprinted polymers: the next generation. doi
  40. (2006). Molecularly imprinted thin film self-assembled on piezoelectric quartz crystal surface by the sol-gel process for protein recognition. doi
  41. (2005). Non-covalent imprinting of phosphorous esters. doi
  42. (2004). Polyacrylamide gels with electrostatic functional groups for the molecular imprinting of lysozyme. doi
  43. (2006). Porphyrin cored hyperbranched polymers as heme protein models. doi
  44. (2006). Protein recognition via surface molecularly imprinted polymer nanowires. doi
  45. (2006). Protein-imprinted soft-wet gel composite microspheres with magnetic susceptibility II. doi
  46. (2006). Quantification and confocal imaging of protein specific molecularly imprinted polymers. doi
  47. (2006). Selective protein capture by epitope imprinting. doi
  48. (2006). Soft-wet polyacrylamide gel beads with the imprinting of bovine serum albumin. doi
  49. (2001). Surface-grafted molecularly imprinted polymers for protein recognition. doi
  50. (2004). Synthesis and applications of hyperbranched polymers. doi
  51. (2006). Synthesis of polyacrylamide gel beads with electrostatic functional groups for the molecular imprinting of bovine serum albumin. doi
  52. (2002). Synthetic hosts by monomolecular imprinting inside dendrimers. doi
  53. (2004). Synthetic hosts via molecular imprinting – are universal synthetic antibodies realistically possible? doi
  54. (2005). Template imprinting amphoteric polymer for the recognition of proteins. doi
  55. (2006). Templated xerogels as platforms for biomolecule-less biomolecule sensors. doi
  56. (2006). The Chemistry of Polymers (3rd edn),
  57. (2006). The microcontact imprinting of proteins: The effect of cross-linking monomers for lysozyme, ribonuclease A and myoglobin. doi
  58. (2000). The use of immobilized templates - A new approach in molecular imprinting. doi
  59. (2001). Towards molecularly imprinted polymers selective to peptides and proteins. The epitope approach. doi
  60. (2005). Urea host monomers for stoichiometric molecular imprinting of oxyanions. doi
  61. (2005). Use of metal co-ordination for controlling imprinted polymers.
  62. (2006). Using protein templates to direct the formation of thin-film polymer surfaces. doi

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.