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Inferential framework for nonstationary dynamics. II, Application to a model of physiological signaling

By Andrea Duggento, Dmitri G. Luchinsky, Vadim N. Smelyanskiy, I. A. Khovanov and P. V. E. McClintock


The problem of how to reconstruct the parameters of a stochastic nonlinear dynamical system when these are time-varying is considered in the context of online decoding of physiological information from neuron signaling activity. To model the spiking of neurons, a set of FitzHugh-Nagumo (FHN) oscillators is used. It is assumed that only a fast dynamical variable can be detected for each neuron, and that the monitored signals are mixed by an unknown measurement matrix. The Bayesian framework introduced in Paper I (Phys. Rev. E 77, 06110500 (2008)) is applied both for reconstruction of the model parameters and elements of the measurement matrix, and for inference of the time-varying parameters in the non-stationary system. It is shown that the proposed approach is able to reconstruct unmeasured (hidden) slow variables of the FHN oscillators, to learn to model each individual neuron, and to track continuous, random and step-wise variations of the control parameter for each neuron in real time

Topics: QA, TA
Publisher: 'American Physical Society (APS)'
Year: 2008
DOI identifier: 10.1103/PhysRevE.77.061106
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