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Neuregulins in the nucleus

By C.M. McClelland and William J. Gullick

Abstract

The neuregulins are a subset of the ligands for the epidermal growth factor receptor family\ud of receptors. They can bind to these receptors and evoke a range of cellular responses. Some of\ud the neuregulins have however been found in the cell nucleus associated with nucleoli and intrachromatin\ud granules. This brief review summarises the data for nuclear expression obtained from\ud observations on normal and malignant tissues and the various laboratory experiments conducted to\ud explore the system. Finally, we discuss the possible functions that could result from intra-nuclear\ud expression of these molecules

Topics: Q, RC0254
Publisher: Humanna Press
Year: 2009
OAI identifier: oai:kar.kent.ac.uk:22653
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