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Solid-phase, multicomponent reactions of methyleneaziridines: Synthesis of 1,3-disubstituted propanones

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Abstract

[GRAPHICS] Polymer-supported methyleneaziridines undergo ring opening by Grignard reagents under copper catalysis to yield metalloenamines which are alkylated in situ to yield ketimines. Filtration and washing of these Merrifield resin-bound intermediates prior to hydrolysis provides the corresponding 1,3-disubstituted propanones in a high state of purity without recourse to column chromatography

Topics: QD
Publisher: AMER CHEMICAL SOC
OAI identifier: oai:wrap.warwick.ac.uk:34401
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