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Pathological interactions with the timing of birth and uterine activation

By Roger Smith, Dirk Van Helden, Jon Hirst, Tamas Zakar, Mark Read, Eng-Cheng Chan, Hannah Palliser, Dimitris Grammatopoulos, Richard Nicholson and Helena C. Parkington


The physiological processes that regulate the onset of parturition and birth are slowly being elucidated, and the points at which pathology can intervene are becoming more apparent. The data support the view that multiple pathways lead to myometrial activation. The clinical corollary is that combinations of tocolytics that operate via different mechanisms may be more effective than single agents. It may also be necessary to divide preterm labour into groups based on underlying mechanisms and to tailor therapy accordingly

Topics: RG
Publisher: Blackwell Publishing
Year: 2007
DOI identifier: 10.1111/j.1479-828x.2007.00775.x
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