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Solubility of Budesonide, Hydrocortisone, and Prednisolone in Ethanol plus Water Mixtures at 298.2 K

By Hany S.M. Ali, Peter York, Nicholas Blagden, S. Soltanpour, W.E. Jr. Acree and A. Jouyban

Abstract

noExperimental solubilities of budesonide, hydrocortisone, and prednisolone in ethanol + water mixtures at 298.2\ud K are reported. The solubility of drugs was increased with the addition of ethanol and reached the maximum\ud values of the volume fractions of 90 %, 80 %, and 80 % of ethanol. The Jouyban-Acree model was used to fit\ud the experimental data, and the solubilities were reproduced using previously trained versions of the Jouyban-Acree\ud model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the\ud models were 5.1 %, 6.4 %, 37.7 %, and 35.9 %, respectively, for the fitted model, the trained version for ethanol\ud + water mixtures, and generally trained versions for various organic solvents + water mixtures. Solubilities\ud were also predicted by a previously established log-linear model of Yalkowsky with the OMRD of 53.8 %

Topics: Solubility, Crystal engineering, Budesonide, Hydrocortisone, Prednisolone, Ethanol and water mixtures
Year: 2010
DOI identifier: 10.1021/je900376r
OAI identifier: oai:bradscholars.brad.ac.uk:10454/4853
Provided by: Bradford Scholars
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