Skip to main content
Article thumbnail
Location of Repository

The immunomodulatory properties of messenchymal stem cells and their use for immunotherapy.

By Martin J. Hoogduijn, F. Popp, R. Verbeek, Mojgan Masoodi, Anna Nicolaou, C. Baan and M-H. Dehlke

Abstract

noThere is growing interest in the use of mesenchymal stem cells (MSC) for immune therapy. Clinical trials that use MSC for treatment of therapy resistant graft versus host disease, Crohn's disease and organ transplantation have initiated. Nevertheless, the immunomodulatory effects of MSC are only partly understood. Clinical trials that are supported by basic research will lead to better understanding of the potential of MSC for immunomodulatory applications and to optimization of such therapies. In this manuscript we review some recent literature on the mechanisms of immunomodulation by MSC in vitro and animal models, present new data on the secretion of pro-inflammatory and anti-inflammatory cytokines, chemokines and prostaglandins by MSC under resting and inflammatory conditions and discuss the hopes and expectations of MSC-based immune therapy

Topics: Mesenchymal stem cells, Prostaglandins, Immunomodulation, Cytokines, Immune therapy, Organ transplantation
Publisher: Elsevier
Year: 2010
DOI identifier: 10.1016/j.intimp.2010.06.019
OAI identifier: oai:bradscholars.brad.ac.uk:10454/4576
Provided by: Bradford Scholars
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://hdl.handle.net/10454/45... (external link)
  • http://dx.doi.org/10.1016/j.in... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.