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Prenylated flavonoid derivatives from the bark of Erythrina addisoniae.

By W. Watjen, A-K. Suckow-Schnitker, R. Rohrig, A. Kulawik, Jonathan A. Addae-Kyereme, Colin W. Wright and C.M. Passreiter

Abstract

noTwo new prenylated flavanones, 2S-3¿-(2-hydroxy-3-methylbut-3-enyl)licoflavone-4¿-methyl ether (3) and 2S-3¿-(2-\ud hydroxy-3-methylbut-3-enyl)abyssinone II (4), and four known flavanones (1, 2, 5, 6) were isolated from the stem bark\ud of Erythrina addisoniae. The structures were elucidated on the basis of their spectroscopic and physicochemical data.\ud None of the compounds showed antioxidative properties. 4¿-Methylabyssinone V (1) and abyssinoflavanone VII (6)\ud showed moderate cytotoxic activity (IC50 ) 5 and 3.5 ¿mol/L, respectively), but apoptosis (caspase-3/7-activation,\ud nuclear fragmentation) was selectively induced by abyssinoflavanone VII (6)

Topics: Erythrina, Prenylated flavonoids
Publisher: American Chemical Society
Year: 2008
DOI identifier: 10.1021/np070417j
OAI identifier: oai:bradscholars.brad.ac.uk:10454/4532
Provided by: Bradford Scholars
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