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Steroids from an Australian sponge Psammoclema sp.

By Ian P. Holland, Adam McCluskey, Jennette A. Sakoff, Jayne Gilbert, Ngoc Chau, Phillip J. Robinson, Cherie A Motti, Anthony D. Wright and Ian A. Van Altena


Investigation of an extract of the Australian marine sponge Psammoclema sp. for dynamin I inhibitory activity led to the isolation of four new trihydroxysterols (1−4) related to aragusterol G. These compounds were largely identified by 1D and 2D NMR spectroscopic methods. While 1 was found to be inactive in the dynamin bioassay, bioassays did reveal that compounds 1−4 inhibited the growth of colorectal, breast, ovarian, and prostate cancer cell lines (GI₅₀ 5−27 μM). The additional insight that these new compounds give to previous SAR studies is discussed briefly

Topics: Psammoclema sp., steroids, cancer, SAR studies
Publisher: American Chemical Society
Year: 2009
DOI identifier: 10.1021/np800688f
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