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Perceptual functions of perirhinal cortex in rats: zero-delay object recognition and simultaneous oddity discriminations

By Susan J. Bartko, Boyer D. Winters, Rosemary A. Cowell, Lisa M. Saksida and Timothy J. Bussey

Abstract

The perirhinal cortex (PRh) is widely accepted as having an important role in object recognition memory in humans and animals. Contrary to claims that PRh mediates declarative memory exclusively, previous evidence suggests that PRh has a role in the perceptual processing of complex objects. In the present study, we conducted an examination of the possible role of PRh in perceptual function in rats.Weexamined whether bilateral excitotoxic lesions ofPRhorPPRh(perirhinal plus postrhinal cortices) in the rat would cause deficits in a zero-delay object-recognition task and a simultaneous oddity discrimination task. Both of these tasks measured spontaneous (untrained, unrewarded) behavior, and the stimuli in these experiments were manipulated to produce varying levels of perceptual difficulty. As predicted by simulations using a computational model, rats with PPRh lesions were impaired in object recognition when the stimuli to be discriminated were manipulated to share many features in common. Furthermore, rats with PPRh and PRh lesions were impaired in a simultaneous oddity discrimination task when the stimuli to be discriminated were manipulated explicitly to be more perceptually similar. These findings provide support for the idea that PRh in the rat is important for the perceptual processing of complex objects, in addition to its well established role in memory

Topics: QA76
Publisher: Soc of Neuroscience
Year: 2007
OAI identifier: oai:kar.kent.ac.uk:24043

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  1. (2006a) Differentiating the roles of the hippocampus and perirhinal cortex in processes beyond long-term declarativememory: a double dissociation in dementia.
  2. (2006). Abnormal categorization and perceptual learning in patients with hippocampal damage.
  3. (2002). Against memory systems. doi
  4. (2001). Borders and cytoarchitecture of the perirhinal and postrhinal cortices in the rat. doi
  5. (1998). Differential neuronal encoding of novelty, familiarity, and recency in regions of the anterior temporal lobe. doi
  6. (1999). Dissociation between the effects of damage to perirhinal cortex and area TE. Learn Mem 6:572–599.
  7. (2002). Dissociation in retrogradememory for object discriminations and object recognition in rats with perirhinal cortex damage. doi
  8. (2002). Dissociation in retrogradememoryforobjectdiscriminationsandobjectrecognitioninrats with perirhinal cortex damage. doi
  9. (2004). Double dissociation between the effects of peri-postrhinal cortex and hippocampal lesions on tests of object recognition and spatial memory:heterogeneityoffunctionwithinthetemporallobe.JNeurosci24:
  10. (1993). Effects on visual recognition of combined and separate ablations of the entorhinal and perirhinal cortex in rhesus monkeys.
  11. (1999). Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition. doi
  12. (1997). Extensive cytotoxic lesions involving both the rhinal cortices and area TE impair recognition but spare spatial alternation in the rat. doi
  13. Graham KS (2006a) Differentiating the roles of the hippocampus and perirhinal cortex in processesbeyondlong-termdeclarativememory:adoubledissociationin dementia.
  14. Graham KS (2006b) Perirhinal cortex activity during visual object discrimination: an eventrelated fMRI study. doi
  15. (2005). Hippocampal lesions that abolish spatial maze performance spare object recognition memory at delays of up to 48 hours. doi
  16. (2005). Hippocampallesionsthatabolish spatial maze performance spare object recognition memory at delays of up to 48 hours.
  17. (2004). Impaired object recognition with increasing levels of feature ambiguity in rats with perirhinal cortex lesions. doi
  18. (1997). Impairment of visual object-discrimination learning after perirhinal cortex ablation. doi
  19. (2003). Impairments in visual discrimination after perirhinal cortex lesions: testing “declarative” vs. “perceptual-mnemonic” views of perirhinal cortex function. doi
  20. (1993). Implicit memory: a selective review. Annu Rev Neurosci 16:159–182. doi
  21. (2005). Intact visual discrimination of complex and feature-ambiguous stimuli in the absence of perirhinal cortex. doi
  22. (2006). Intact visual perception in memory-impaired patients with medial temporal lobe lesions. doi
  23. (2000). Intact visual perceptual discrimination in humans in the absence of perirhinal cortex. doi
  24. (2006). Lack of evidence for a role of medial temporal lobe structures in visual perception. doi
  25. (1993). Lesions of the perirhinal and parahippocampal cortices in the monkey produce longlasting memory impairment in the visual and tactual modalities.
  26. (2003). Modeling hippocampal and neocortical contributions to recognition memory: a complementary-learningsystems approach. Psychol Rev 110:611–646. doi
  27. (2005). Monkey perirhinal cortex is critical for visualmemory, but not for visual perception: reexamination of the behavioral evidence from monkeys.
  28. (2005). Monkeyperirhinalcortexiscriticalforvisualmemory, but not for visual perception: reexamination of the behavioral evidence from monkeys.
  29. (2004). Multiple memory systems: fact or fiction?
  30. (2005). Object memory and perception in the medial temporal lobe: an alternative approach. doi
  31. (2005). Objectmemoryandperceptioninthemedial temporal lobe: an alternative approach.
  32. (2000). Perception and recognition memory in monkeys following lesions of area TE and perirhinal cortex. doi
  33. (2000). Perceptual and mnemonic matching-to-sample in humans: contributions of the hippocampus, perirhinal, and other medial temporal lobe cortices. doi
  34. (1999). Perceptual-mnemonic functions of the perirhinal cortex. Trends Cogn Sci 3:142–151.
  35. (1998). Perirhinal cortex ablation impairs visual object identification. doi
  36. (2001). Perspectives on object-recognition memory following hippocampal damage: lessons from studies in rats. doi
  37. (1994). Preserved recognition memory for small sets, and impaired stimulus identification for large sets, following rhinal cortex ablations in monkeys. doi
  38. (2003). Recognition memory for complex visual discriminations is influenced by stimulus interference in rodents with perirhinal cortex damage. doi
  39. (2001). Recognition memory: what are the roles of the perirhinal cortex and hippocampus? Nat Rev Neurosci 2:51–61. doi
  40. (2001). Recognitionmemory:whataretherolesof the perirhinal cortex and hippocampus?
  41. (1994). Rhinal cortex lesions and object recognition in rats. doi
  42. (1994). Rhinalcortexlesionsandobjectrecognitionin rats.
  43. Saksida LM,Murray EA (2002) Perirhinal cortex resolves feature ambiguity in complex visual discriminations. doi
  44. (2001). Selective perceptual impairments after perirhinal cortex ablation.
  45. (2005). Specialization in themedial temporal lobe for processing of objects and scenes.Hippocampus 15:782–797. doi
  46. (2005). Specialization in themedialtemporallobeforprocessingofobjectsandscenes.Hippocampus 15:782–797. doi
  47. (1998). The human perirhinal cortex and recognition memory. Hippocampus 8:330–339. doi
  48. (1991). The medial temporal lobe memory system. doi
  49. (2002). The organization of visual object representations: a connectionist model of effects of lesions in perirhinal cortex. doi
  50. (1997). The rat brain in stereotaxic coordinates. doi
  51. (2004). Visual presentation of novel objects and new spatial arrangements of objects differentially activates the medial temporal lobe subareas in humans. doi
  52. (2006). Why does brain damage impair memory? A connectionist model of object recognition memory in perirhinal cortex. doi
  53. (2006). Whydoesbraindamageimpairmemory? A connectionist model of object recognition memory in perirhinal cortex.

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