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Repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors?

By Tihomir P. Obrenovitch, P.L. Chazot and O.V. Godukhin


NoIn the November issue (2001) of Neuroscience Letters, Holmin et al. (Neurosci. Lett. 314 (2001) 151) reported that the synthesis of the intermediate filament protein nestin was upregulated by potassium-induced depolarization in the rat cortex. In this letter, we provide supplementary evidence that repeated cortical spreading depression elicited by potassium induces a delayed upregulation of nestin. However, we argue against the authors' conclusion, Nestin expression was N-methyl-D-aspartate (NMDA)-receptor dependent since dizocilpine (MK-801) treatment abolished the response because spreading depression itself is very sensitive to NMDA-receptor block, and the drug treatment was initiated prior to potassium application to the cortex in Holmin et al.'s study

Topics: Neuroglia, Central nervous system, Brain vertebrata, Mammalia, Rodentia, Rat, Mouse, Gene expression, Astrocyte, NMDA receptor, Cerebral cortex, Spreading depression
Year: 2002
DOI identifier: 10.1016/S0304-3940(02)00046-0
OAI identifier:
Provided by: Bradford Scholars
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