Skip to main content
Article thumbnail
Location of Repository

Repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors?

By Tihomir P. Obrenovitch, P.L. Chazot and O.V. Godukhin

Abstract

NoIn the November issue (2001) of Neuroscience Letters, Holmin et al. (Neurosci. Lett. 314 (2001) 151) reported that the synthesis of the intermediate filament protein nestin was upregulated by potassium-induced depolarization in the rat cortex. In this letter, we provide supplementary evidence that repeated cortical spreading depression elicited by potassium induces a delayed upregulation of nestin. However, we argue against the authors' conclusion, Nestin expression was N-methyl-D-aspartate (NMDA)-receptor dependent since dizocilpine (MK-801) treatment abolished the response because spreading depression itself is very sensitive to NMDA-receptor block, and the drug treatment was initiated prior to potassium application to the cortex in Holmin et al.'s study

Topics: Neuroglia, Central nervous system, Brain vertebrata, Mammalia, Rodentia, Rat, Mouse, Gene expression, Astrocyte, NMDA receptor, Cerebral cortex, Spreading depression
Year: 2002
DOI identifier: 10.1016/S0304-3940(02)00046-0
OAI identifier: oai:bradscholars.brad.ac.uk:10454/3115
Provided by: Bradford Scholars
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://hdl.handle.net/10454/31... (external link)
  • http://dx.doi.org/10.1016/S030... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.