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Crystallisation of pure anhydrous polymorphs of carbamazepine by solution enhanced dispersion with supercritical fluids (SEDS¿).

By Anthony D. Edwards, Boris Yu. Shekunov, Andreas Kordikowski, Robert T. Forbes and Peter York

Abstract

NoPure anhydrous polymorphs of carbamazepine were prepared by solution-enhanced dispersion with supercritical fluids (SEDSTM). Crystallization of the polymorphs was studied. Mechanisms are proposed that consider the thermodynamics of carbamazepine, supersaturation in the SEDSTM process, and the binary phase equilibria of organic solvents and the carbon dioxide antisolvent. -Carbamazepine was crystallized at high supersaturations and low temperatures, -carbamazepine crystallized from a methanol-carbon dioxide phase split, and -carbamazepine crystallized via nucleation at high temperatures and low supersaturation

Topics: Crystallization, SEDS, Dispersion, Polymorphism
Year: 2001
DOI identifier: 10.1002/jps.1065
OAI identifier: oai:bradscholars.brad.ac.uk:10454/3977
Provided by: Bradford Scholars
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