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Molecular basis for dimethylsulfoxide (DMSO) Action on Lipid Membrances

By Jamshed Anwar, M.G. Noro, R. Notman and B. O'Malley

Abstract

NoDimethylsulfoxide (DMSO) is an aprotic solvent that has the ability to induce cell fusion and cell differentiation and enhance the permeability of lipid membranes. It is also an effective cryoprotectant. Insights into how this molecule modulates membrane structure and function would be invaluable toward regulating the above processes and for developing chemical means for enhancing or hindering the absorption of biologically active molecules, in particular into or via the skin. We show here by means of molecular simulations that DMSO can induce water pores in dipalmitoyl-phosphatidylcholine bilayers and propose this to be a possible pathway for the enhancement of penetration of actives through lipid membranes. DMSO also causes the membrane to become floppier, which would enhance permeability, facilitate membrane fusion, and enable the cell membrane to accommodate osmotic and mechanical stresses during cryopreservation

Topics: Dimethylsulfoxide, DMSO, Lipid membranes
Year: 2006
DOI identifier: 10.1021/ja063363t
OAI identifier: oai:bradscholars.brad.ac.uk:10454/3338
Provided by: Bradford Scholars
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