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Time-resolved x-ray scattering using synchrotron radiation applied to the study of a polymorphic transition in carbamazepine.

By Robert T. Forbes, Anthony D. Edwards, Boris Yu. Shekunov, J Grossmann and Peter York

Abstract

NoThe thermodynamic status of -carbamazepine has been clarified using equilibrium solubility measurements, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), heated X-ray powder diffraction (XRPD), and temperature-controlled X-ray scattering techniques. -Carbamazepine is the least stable of the three well-characterized anhydrous polymorphs of carbamazepine at 25°C. In addition, it was confirmed that -carbamazepine undergoes an exothermic transition to -carbamazepine at 130°C. The novel technique of time-resolved simultaneous small- and wide-angle X-ray scattering has been successfully applied to monitor this transition in situ. It was concluded that -carbamazepine has a monotropic relationship with -carbamazepine

Topics: Crystallization, Nomenclature, Physical stability, Polymorphism
Year: 2001
DOI identifier: 10.1002/jps.1064
OAI identifier: oai:bradscholars.brad.ac.uk:10454/4018
Provided by: Bradford Scholars
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