[[abstract]]In this paper, a framework to automatically generate a set of parameters of PID (proportional, integral and derivative) controllers for the twin rotor multi-input multi-output system (TRMS) by using a simplified genetic algorithm (GA) is proposed. The simplified GA is proposed for tuning the PID parameters. The sequential search method is used to find the desired crossover point for the crossover operation. Finally, the optimal PID parameters are applied to the TRMS. Simulation results and experimental verification are demonstrated to show the effectiveness and performance of the proposed method.