[[abstract]]The purpose of this study is to examine the effects of 6 weeks of sub-maximal exercise on the liver function and ratings of perceived fatigue of the students infected with hepatitis B. The study analyzed (hematological test, serum protein, serum enzyme and ratings of perceived exertion（RPE）, exercise intensity, exercise of heart rates ) of the infected students to understand the effects of the exercise program. Participating subjects are chosen from high school male students with average age of 17.3. Total of twenty eight subjects are given general health check-up and blood test before dividing into three test groups: 12 Hepatitis B carriers whose liver is functioning normally（B1）, 6 Hepatitis B carriers who has liver problem（B2）, and 10 without Hepatitis B（B3）. The subjects were asked to use treadmill for 20 minutes to reach between the 85~ 70 percentages heart rate reserve. This training is performed three times a week, 30 minutes each session for 6 weeks. During the training, the subject’s ratings of perceived fatigue were taken and analyzed（2-way ANOVA mixed design）on the week pre, 2, 4, and 6 before and after the exercise sessions until 8th week. The study found lymphocytes increase after exercise training, but hematocrit lowered. In addition, albumin decreased obviously. Even though AST and ALT do not demonstrate obvious before and after exercise training, AST and ALT lowered among chronic carriers, closer to the normal value. Moreover, ALP and r-GPT indicate the similar tendency. All three groups demonstrated an increase in CPK and LDH but the number dropped back down. On the RPE that decreased significantly in each group（p<.05）after exercise training. The B1 group decreased 22.55%, the B2 group decreased 20.97%, the B3 group decreased 21.63%, but all three groups demonstrated an increase on 8th week. In addition, intensity increased obviously（p<.05）. The B1 group increased 6.20%, the B2 group increased 20.97%, the B3 group increased 20.44%. Moreover, all three groups demonstrated at target heart rates in exercise of heart rates, but the B1 group higher obviously（p<.05）than the others. The study found that given regular and mid to high intensity exercise or training, patients with abnormal liver function will be promoted physical ability and lowered ratings of perceived exertion（RPE）. Moreover, exercise training revealed positive influence in physiology and psychology of patients with hepatitis B chronic. Therefore, this study can be used as reference for hepatitis B patients interested in regular and mid to high intensity exercise or training.
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